Special stains and histochemistry are laboratory techniques used in clinical pathology to identify specific substances, structures, cells, and tissue components that may not be clearly visible with routine staining. These tests can provide additional information to help pathologists examine biopsy and tissue samples and reach a more accurate diagnosis.
What Is Histochemistry?
Histochemistry involves applying carefully selected stains to tissue sections to highlight particular components such as carbohydrates, connective tissue, pigments, microorganisms, mucin, and other cellular substances. A special stain test may be recommended when routine Hematoxylin and Eosin (H&E) staining does not provide enough information.
When Are Special Stains Recommended?
Depending on the tissue sample and clinical question, special stains may assist in evaluating infections, tissue deposits, connective tissue changes, gastrointestinal conditions, liver disorders, and other pathological findings. The specific stain used is selected by the pathologist based on the patient's clinical history and microscopic findings.
Why Choose Accurate Histopathology Testing?
Reliable histopathology and histochemistry testing depends on appropriate specimen handling, staining techniques, microscopic examination, and professional interpretation. Your doctor or pathologist can determine whether a special stain is appropriate for your sample and clinical situation.